Rust on the Brain from Microbleeds and Its Relevance to Alzheimer Studies: Invited Commentary on Cacciottolo Neurobiology of Aging, 2016.

Bibliographic Collection: 
CARTA-Inspired Publication
Publication Type: Journal Article
Authors: Cacciottolo, M; Morgan, TE; Finch, CE
Year of Publication: 2016
Journal: J Alzheimers Dis Parkinsonism
Volume: 6
Date Published: Nov
Publication Language: eng
Accession Number: 28042517

Cerebral microbleeds (MB) and small vessel disease (SVD) with congophilic arterial angiopathy (CAA) are increasingly recognized as a variable factor in AD cognitive impairments. This commentary on our recent report on sex-ApoE interactions in MBs published this February, briefly explores three aspects of MBs that could not be fully discussed therein: I, A possible gap between the prevalence of MBs as detected by MRI and post mortem analysis; II, The role of hemoglobin-degradation products in amyloid-attributed neurodegenerative changes; and III, Possible assessment of MB by cerebrospinal fluid (CSF) assays for iron-related markers to better screen patient subgroups for AD interventions.

Author Address:

Leonard Davis School of Gerontology, Los Angeles CA, USA. Leonard Davis School of Gerontology, Los Angeles CA, USA; Department of Neurobiology, Dornsife College, University of Southern California, Los Angeles CA, USA.