Segmental duplications and the evolution of the primate genome.
Bibliographic Collection:
MOCA Reference, APE
Publication Type: Journal Article
Authors: Samonte, Rhea Vallente; Eichler, Evan E
Year of Publication: 2002
Journal: Nat Rev Genet
Volume: 3
Issue: 1
Pagination: 65-72
Date Published: 2002 Jan
Publication Language: eng
ISSN: 1471-0056
Keywords: Amino Acid Sequence, Animals, Biological Evolution, Chromosomes, Human, Evolution, Molecular, Exons, Gene Duplication, Genome, Human, Haplorhini, Humans, Molecular Sequence Data, Polyploidy, Sequence Homology, Amino Acid
Abstract:
Initial human genome sequence analysis has revealed large segments of nearly identical sequence in particular chromosomal regions. The recent origin of these segments and their abundance (approximately 5%) has challenged investigators to elucidate their underlying mechanism and role in primate genome evolution. Although the precise fraction is unknown, some of these duplicated segments have recently been shown to be associated with rapid gene innovation and chromosomal rearrangement in the genomes of man and the great apes.
DOI: 10.1038/nrg705
Alternate Journal: Nat. Rev. Genet.
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