Spontaneous heart disease in the adult chimpanzee (Pan troglodytes).

Bibliographic Collection: 
MOCA Reference, APE
Publication Type: Journal Article
Authors: Seiler, Brittany M; Dick, Edward J; Guardado-Mendoza, Rodolfo; VandeBerg, John L; Williams, Jeff T; Mubiru, James N; Hubbard, Gene B
Year of Publication: 2009
Journal: J Med Primatol
Volume: 38
Issue: 1
Pagination: 51-8
Date Published: 2009 Feb
Publication Language: eng
ISSN: 0047-2565
Keywords: Animals, Ape Diseases, Body Weight, Cardiomyopathies, Diet, Disease Models, Animal, Environment, Female, Male, Myocardium, Pan troglodytes, Retrospective Studies

BACKGROUND: A high incidence of heart disease, especially idiopathic cardiomyopathy (IC), is seen in chimpanzees (Pan troglodytes).

METHODS: We reviewed clinical records and necropsy reports of 87 adult chimpanzees for possible causes of heart disease/IC. We examined age, sex, cause of death, weight, diet, environment, infectious diseases, experimental uses and clinical pathology.

RESULTS: The overall prevalence of heart disease in chimpanzees was 67.81%; the prevalence of IC was 51.72%. The prevalence of IC was significantly higher in males (60.32%) than that in females (29.17%, P = 0.009). The prevalence of other heart disease was higher in females (25%) than that in males (12.70%, P = 0.165). Heart failure occurred in 47.13% of chimpanzees. Heart disease was the primary cause of death in 34.49% of chimpanzees; 29.88% died of unknown causes.

CONCLUSIONS: We found no evidence that diet, environment, viral agents, experimental use or disease exposure contributed to the deaths resulting from IC in chimpanzees.

DOI: 10.1111/j.1600-0684.2008.00307.x
Alternate Journal: J. Med. Primatol.
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