Synergy between angiotensin and aldosterone in evoking sodium appetite in baboons.

Bibliographic Collection: 
CARTA-Inspired Publication
Publication Type: Journal Article
Authors: Shade, RE; Blair West JR; Carey, KD; Madden, LJ; Weisinger, RS; Denton, DA
Year of Publication: 2002
Journal: Am J Physiol Regul Integr Comp Physiol
Volume: 283
Number: 5
Pagination: R1070-8
Date Published: Nov/2002
Publisher: United States
Publication Language: eng
Accession Number: 12376400
Keywords: &, Adrenal Cortex Hormones/metabolism, Aldosterone/administration, Angiotensins/administration, Animals, Appetite/*drug effects, Blood Pressure/drug effects/physiology, Body Weight/drug effects, dosage/*pharmacology, Drug Syne
Abstract:

The synergy between ANG II and aldosterone (Aldo) in the induction of salt appetite, extensively studied in rats, has been tested in baboons. ANG II was infused intracerebroventricularly at 0.5 or 1.0 microg/h; Aldo was infused subcutaneously at 20 microg/h. Separate infusions over 7 days had no significant effect on the daily intake of 300 mM NaCl. Concurrent infusions, however, increased daily NaCl intake approximately 10-fold and daily water intake approximately 2.5-fold. In addition, the combined infusions caused 1) a reduction in daily food intake, 2) changes in blood composition indicative of increased vasopressin release, and 3) changes of urinary excretion rates of cortisol and Aldo indicative of increased ACTH release. Arterial blood pressure, measured in two baboons, rose during concurrent ANG II and Aldo treatment. These results indicate a potent synergy between central ANG II and peripheral Aldo in stimulating salt appetite in baboons. At the same time, other ANG II-specific brain mechanisms concerned with water intake, food intake, vasopressin release, ACTH release, and blood pressure regulation appear to have been activated by the same type of synergy. These central enhancement processes have never been previously demonstrated in primates.

Notes:

Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1070-8.

Author Address:

Department of Physiology and Medicine, Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245-0549, USA. bshade@sfbr.org

Export: