Uniquely human evolution of sialic acid genetics and biology

Bibliographic Collection: 
CARTA-Inspired Publication, APE
Publication Type: Journal Article
Authors: Ajit Varki
Year of Publication: 2010
Journal: Proc Natl Acad Sci U S A
Volume: 107 Suppl
Edition: 2010/05/07
Pagination: 8939-46
Date Published: May 11
Publication Language: eng
ISBN Number: 1091-6490 (Electronic)00
Keywords: Antigens, Arginine, CD/genetics, Differentiation, Environment, Female, Genetic, Humans, Macrophages/metabolism, Male, Membrane Glycoproteins/*genetics, Models, Myelomonocytic/genetics, N-Acetylneuraminic Acid/*metabolism, Polysaccharides/metabol

Darwinian evolution of humans from our common ancestors with nonhuman primates involved many gene-environment interactions at the population level, and the resulting human-specific genetic changes must contribute to the "Human Condition." Recent data indicate that the biology of sialic acids (which directly involves less than 60 genes) shows more than 10 uniquely human genetic changes in comparison with our closest evolutionary relatives. Known outcomes are tissue-specific changes in abundant cell-surface glycans, changes in specificity and/or expression of multiple proteins that recognize these glycans, and novel pathogen regimes. Specific events include Alu-mediated inactivation of the CMAH gene, resulting in loss of synthesis of the Sia N-glycolylneuraminic acid (Neu5Gc) and increase in expression of the precursor N-acetylneuraminic acid (Neu5Ac); increased expression of alpha2-6-linked Sias (likely because of changed expression of ST6GALI); and multiple changes in SIGLEC genes encoding Sia-recognizing Ig-like lectins (Siglecs). The last includes binding specificity changes (in Siglecs -5, -7, -9, -11, and -12); expression pattern changes (in Siglecs -1, -5, -6, and -11); gene conversion (SIGLEC11); and deletion or pseudogenization (SIGLEC13, SIGLEC14, and SIGLEC16). A nongenetic outcome of the CMAH mutation is human metabolic incorporation of foreign dietary Neu5Gc, in the face of circulating anti-Neu5Gc antibodies, generating a novel "xeno-auto-antigen" situation. Taken together, these data suggest that both the genes associated with Sia biology and the related impacts of the environment comprise a relative "hot spot" of genetic and physiological changes in human evolution, with implications for uniquely human features both in health and disease.


Proc Natl Acad Sci U S A. 2010 May 11;107 Suppl 2:8939-46. doi: 10.1073/pnas.0914634107. Epub 2010 May 5.

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Alternate Journal: Proceedings of the National Academy of Sciences of the United States of America
Author Address:

Center for Academic Research and Training in Anthropogeny, Glycobiology Research and Training Center, Departments of Medicine and Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA. a1varki@ucsd.edu