What do you mean, "epigenetic"?

Bibliographic Collection: 
Publication Type: Journal Article
Authors: Deans, Carrie; Maggert, Keith A
Year of Publication: 2015
Journal: Genetics
Volume: 199
Issue: 4
Pagination: 887-96
Date Published: 2015 Apr
Publication Language: eng
ISSN: 1943-2631
Keywords: Animals, Epigenesis, Genetic, Epigenomics, Humans, Terminology as Topic

Interest in the field of epigenetics has increased rapidly over the last decade, with the term becoming more identifiable in biomedical research, scientific fields outside of the molecular sciences, such as ecology and physiology, and even mainstream culture. It has become increasingly clear, however, that different investigators ascribe different definitions to the term. Some employ epigenetics to explain changes in gene expression, others use it to refer to transgenerational effects and/or inherited expression states. This disagreement on a clear definition has made communication difficult, synthesis of epigenetic research across fields nearly impossible, and has in many ways biased methodologies and interpretations. This article discusses the history behind the multitude of definitions that have been employed since the conception of epigenetics, analyzes the components of these definitions, and offers solutions for clarifying the field and mitigating the problems that have arisen due to these definitional ambiguities.

DOI: 10.1534/genetics.114.173492
Alternate Journal: Genetics