What does Williams syndrome reveal about the determinants of social behavior?

Bibliographic Collection: 
CARTA-Inspired Publication
Publication Type: Journal Article
Authors: Jarvinen, AM; Bellugi, U
Year of Publication: 2013
Journal: Front Hum Neurosci
Volume: 7
Edition: 2013/07/05
Pagination: 321
Publication Language: eng
ISBN Number: 1662-5161 (Electronic)16
Accession Number: 23825455

Growing evidence on autonomic nervous system (ANS) function in individuals with Williams syndrome (WS) has begun to highlight aberrancies that may have important implications for the social profile characterized by enhanced social motivation and approach. In parallel, neurobiological investigations have identified alterations in the structure, function, and connectivity of the amygdala, as well as prosocial neuropeptide dysregulation, as some of the key neurogenetic features of WS. A recent social approach/withdrawal hypothesis (Kemp and Guastella, 2011) suggests that autonomic cardiac control may play a key role in regulating the relationship between oxytocin (OT) and social behavior. This article discusses evidence from these critical, new strands of research into social behavior in WS, to consider the extent to which data on WS may provide novel insight into the determinants of social behavior. Future research directions are suggested.


Front Hum Neurosci. 2013 Jun 28;7:321. doi: 10.3389/fnhum.2013.00321. Print 2013.

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Alternate Journal: Frontiers in human neuroscience
Author Address:

Laboratory for Cognitive Neuroscience, The Salk Institute for Biological Studies La Jolla, CA, USA.