Atherosclerosis

Certainty Style Key
Hover over keys for definitions:
True   Likely   Speculative
Human Uniqueness Compared to "Great Apes": 
Relative Difference
MOCA Domain: 
MOCA Topic Authors: 

Atherosclerosis with consequent serious cardiovascular diseases appears to be relatively human specific. Non human primates have a lower incidence of spontaneous cardiac and arterial disease. Although cholesterol values are consistently higher in chimpanzees than in humans, there are only rare descriptions of atherosclerotic coronary artery disease. Although coronary atherosclerosis, myointimal thickening with associated lipid deposition, occurs when the non-human primate is manipulated by dietary intervention, the incidence of spontaneous coronary artery atherosclerosis remains markedly lower than that reported for humans. While focal coronary and cerebral artery plaques and diffuse lesions in the aorta were seen at necropsy,  atherosclerosis is considered to be of minor clinical significance in the chimpanzee. While cardiac diseases is a major cause of death in chimpanzees the pathology is myocardial fibrosis rather than ischemic heart disease. 

Related MOCA Topics
Related Topics (hover over title for reason):
Referenced By:
Title Certainty
APOC1 (apolipoprotein C-I) Speculative
End Stage Renal Disease Likely

References

No related publications have been added for this topic