Benign Prostatic Hyperplasia

Benign Prostatic hyperplasia (BPH) has primarily been described in human populations. BPH is an enlargement of the prostate is caused by benign nodular hyperplasia of the prostatic glands and of the stroma. The development of BPH is associated with increased age and higher testosterone levels. BPH is extremely common in human males over the age of 50. Urinary obstruction occurs because the hyperplasia occurs around the urethra. This produces symptoms of frequency, urgency, nocturia, difficulty in starting and in stopping urination BPH does not predispose the individual to cancer. BPH has not been reported in non-human primates.