Diabetes Mellitus

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Human Uniqueness Compared to "Great Apes": 
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Adult onset Diabetes mellitus (Type 2 Diabetes), currently afflicting millions of humans, has been reported for captive chimpanzees. Given relatively high rates of obesity and relative inactivity in captive chimpanzees, this disorder seems to be surprisingly rare. There is no information on the occurrence of Type 2 diabetes in wild great ape populations. There are no reports for gorillas.  So far, there are no reports of type 1 (Juvenile onset) Diabetes in great apes.

 

References

  1. Decoding triancestral origins, archaic introgression, and natural selection in the Japanese population by whole-genome sequencing, Liu, Xiaoxi, Koyama Satoshi, Tomizuka Kohei, Takata Sadaaki, Ishikawa Yuki, Ito Shuji, Kosugi Shunichi, Suzuki Kunihiko, Hikino Keiko, Koido Masaru, et al. , Science Advances, Volume 10, Issue 16, p.eadi8419, (2024)
  2. Genetic diversity of CHC22 clathrin impacts its function in glucose metabolism, Fumagalli, Matteo, Camus Stephane M., Diekmann Yoan, Burke Alice, Camus Marine D., Norman Paul J., Joseph Agnel, Abi-Rached Laurent, Benazzo Andrea, Rasteiro Rita, et al. , eLife, 2019/06/04, Volume 8, p.e41517, (2019)