Protein Expression in the Amygdala
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Humans evolved differences in the expression of calcium-binding proteins and extracellular-matix glycoproteins. Humans show different patterns of expression of the calcium-binding protein calbindin and of chondroitin sulfate proteoglycan than do macaques and rats. No information is available for chimpanzees, however, so it is unclear whether this is a human or an ape-human specialization.
Humans evolved differences in the expression of calcium-binding proteins and extracellular-matix glycoproteins. The calcium-binding protein calbindin (CB) is expressed by fewer neurons in humans than in macaques or rats (Sorvari et al., 1996). Chondroitin sulfate proteoglycan, which can be labeled with the Wisteria floribunda agglutinin (WFA), is reported to be expressed by glial cells (mainly astrocytes) as well as neurons in humans, whereas in macaques and rats, it is expressed exclusively by neurons (Pantazopoulus et al. 2008). No information is available for chimpanzees, however, so it is unclear whether this is a human or an ape-human specialization.
Total number, distribution, and phenotype of cells expressing chondroitin sulfate proteoglycans in the normal human amygdala., , Brain Res, 05/2008, Volume 1207, p.84-95, (2008)
Calretinin-immunoreactive cells and fibers in the human amygdaloid complex., , J Comp Neurol, 05/1996, Volume 369, Issue 2, p.188-208, (1996)