Viral Hepatitis Complications

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Human Uniqueness Compared to "Great Apes": 
Likely Difference
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Humans suffer from several different viral infections causing hepatitis that can sometimes result in long-term complications (chronic active liver damage, cirrhosis and hepatocellular carcinoma). Hepatitis viruses B and C (HBV and HCV) are highly infectious blood-borne viruses that infect millions of people world-wide. Following both infections, a significant proportion of infected humans suffer chronic hepatitis and long-term complications. Chimpanzees can be infected with these viruses, both naturally in the wild, and experimentally in the laboratory. Both HBV and HCV successfully infect and replicate in chimpanzees. However, neither virus seems to cause as high a frequency of long-term complications as is seen in humans. Interestingly, the later liver damage in chronic hepatitis is thought not to be due to the virus per se, but due to the excessive host T cell response to it. In this regard, there is evidence that human T cells are more reactive than those of the chimpanzee. Of course, the experimental infection of chimpanzees with large doses of virus does not mirror what happens in natural human infections. The initial events could also affect the eventual immune response to the virus.

Timing

Timing of appearance of the difference in the Hominin Lineage as a defined date or a lineage separation event. The point in time associated with lineage separation events may change in the future as the scientific community agrees upon better time estimates. Lineage separation events are defined in 2017 as:

  • the Last Common Ancestor (LCA) of humans and old world monkeys was 25,000 - 30,000 thousand (25 - 30 million) years ago
  • the Last Common Ancestor (LCA) of humans and chimpanzees was 6,000 - 8,000 thousand (6 - 8 million) years ago
  • the emergence of the genus Homo was 2,000 thousand (2 million) years ago
  • the Last Common Ancestor (LCA) of humans and neanderthals was 500 thousand years ago
  • the common ancestor of modern humans was 100 - 300 thousand years ago

Definite Appearance: 
100 thousand years ago
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Absolute Lymphocyte Count Speculative
OCLN (Occludin) Speculative

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