Keywords: Animals, Disease, DNA, Mitochondrial, Female, Genetic Speciation, Genetic Variation, Genetics, Medical, Human Migration, Humans, Oxidative Phosphorylation

Abstract:

Environmental adaptation, predisposition to common diseases, and, potentially, speciation may all be linked through the adaptive potential of mitochondrial DNA (mtDNA) alterations of bioenergetics. This Perspective synthesizes evidence that human mtDNA variants may be adaptive or deleterious depending on environmental context and proposes that the accrual of mtDNA variation could contribute to animal speciation via adaptation to marginal environments.

Notes:

http://www.sciencedirect.com/science/article/pii/S0092867415011198

URL: http://www.ncbi.nlm.nih.gov/pubmed/26406369

DOI: 10.1016/j.cell.2015.08.067

Custom 1:

http://www.ncbi.nlm.nih.gov/pubmed/26406369?dopt=Abstract

Alternate Journal: Cell

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