The Alzheimer's disease–protective CD33 splice variant mediates adaptive loss of function via diversion to an intracellular pool
Bibliographic Collection:
CARTA-Inspired Publication
Publication Type: Journal Article
Authors: Siddiqui, SS; Springer, SA; Verhagen, A; Sundaramurthy, V; Alisson-Silva, F; Jiang, W; Ghosh, P; Ajit Varki
Year of Publication: 2017
Journal: J Biol Chem
Volume: 292
Pagination: 15312-15320
Publication Language: eng
Abstract:
The immunomodulatory receptor Siglec-3/CD33 influences risk for late-onset Alzheimer's disease (LOAD), an apparently human-specific post-reproductive disease. CD33 generates two splice variants: a full-length CD33M transcript produced primarily by the “LOAD-risk” allele and a shorter CD33m isoform lacking the sialic acid-binding domain produced primarily from the “LOAD-protective” allele. An SNP that modulates CD33 splicing to favor CD33m is associated with enhanced microglial activity. Individuals expressing more …
Notes:
Times cited: 1
Export:
