Cholera transmission: the host, pathogen and bacteriophage dynamic.

Bibliographic Collection: 
MOCA Reference, APE
Publication Type: Journal Article
Authors: Nelson, Eric J; Harris, Jason B; Morris, J Glenn; Calderwood, Stephen B; Camilli, Andrew
Year of Publication: 2009
Journal: Nat Rev Microbiol
Volume: 7
Issue: 10
Pagination: 693-702
Date Published: 2009 Oct
Publication Language: eng
ISSN: 1740-1534
Keywords: Animals, Bacteriophages, Cholera, Fresh Water, Humans, Vibrio cholerae, Zimbabwe

Zimbabwe offers the most recent example of the tragedy that befalls a country and its people when cholera strikes. The 2008-2009 outbreak rapidly spread across every province and brought rates of mortality similar to those witnessed as a consequence of cholera infections a hundred years ago. In this Review we highlight the advances that will help to unravel how interactions between the host, the bacterial pathogen and the lytic bacteriophage might propel and quench cholera outbreaks in endemic settings and in emergent epidemic regions such as Zimbabwe.

DOI: 10.1038/nrmicro2204
Alternate Journal: Nat. Rev. Microbiol.
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