Codiversification of gut microbiota with humans.

Bibliographic Collection: 
Publication Type: Journal Article
Authors: Suzuki, Taichi A; Fitzstevens, J Liam; Schmidt, Victor T; Enav, Hagay; Huus, Kelsey E; Mbong Ngwese, Mirabeau; Grießhammer, Anne; Pfleiderer, Anne; Adegbite, Bayode R; Zinsou, Jeannot F; Esen, Meral; Velavan, Thirumalaisamy P; Adegnika, Ayola A; Song, Le Huu; Spector, Timothy D; Muehlbauer, Amanda L; Marchi, Nina; Kang, Hyena; Maier, Lisa; Blekhman, Ran; Ségurel, Laure; Ko, GwangPyo; Youngblut, Nicholas D; Kremsner, Peter; Ley, Ruth E
Year of Publication: 2022
Journal: Science
Volume: 377
Issue: 6612
Pagination: 1328-1332
Date Published: 2022 Sep 16
Publication Language: eng
ISSN: 1095-9203
Keywords: Bacteria, Child, Gastrointestinal Microbiome, Host Microbial Interactions, Humans, Metagenome, Oxygen

The gut microbiomes of human populations worldwide have many core microbial species in common. However, within a species, some strains can show remarkable population specificity. The question is whether such specificity arises from a shared evolutionary history (codiversification) between humans and their microbes. To test for codiversification of host and microbiota, we analyzed paired gut metagenomes and human genomes for 1225 individuals in Europe, Asia, and Africa, including mothers and their children. Between and within countries, a parallel evolutionary history was evident for humans and their gut microbes. Moreover, species displaying the strongest codiversification independently evolved traits characteristic of host dependency, including reduced genomes and oxygen and temperature sensitivity. These findings all point to the importance of understanding the potential role of population-specific microbial strains in microbiome-mediated disease phenotypes.

DOI: 10.1126/science.abm7759
Alternate Journal: Science