Comment on "Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens".

Bibliographic Collection:

MOCA Reference, APE

Publication Type: Journal Article

Authors: Yu, Fuli; Hill, R Sean; Schaffner, Stephen F; Sabeti, Pardis C; Wang, Eric T; Mignault, Andre A; Ferland, Russell J; Moyzis, Robert K; Walsh, Christopher A; Reich, David

Year of Publication: 2007

Journal: Science

Volume: 316

Issue: 5823

Pagination: 370

Date Published: 2007 Apr 20

Publication Language: eng

ISSN: 1095-9203

Keywords: Adaptation, Biological, African Continental Ancestry Group, Asian Continental Ancestry Group, Biological Evolution, Brain, European Continental Ancestry Group, Gene Frequency, Haplotypes, Humans, Nerve Tissue Proteins, Polymorphism, Single Nucleotide, Recombination, Genetic, Selection, Genetic, Sequence Analysis, DNA, Time

Abstract:

Mekel-Bobrov et al. (Reports, 9 September 2005, p. 1720) suggested that ASPM, a gene associated with microcephaly, underwent natural selection within the last 500 to 14,100 years. Their analyses based on comparison with computer simulations indicated that ASPM had an unusual pattern of variation. However, when we compare ASPM empirically to a large number of other loci, its variation is not unusual and does not support selection.

DOI: 10.1126/science.1137568

Custom 1:

http://www.ncbi.nlm.nih.gov/pubmed/17446375?dopt=Abstract

Alternate Journal: Science

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