Excavating Neandertal and Denisovan DNA from the genomes of Melanesian individuals.

Bibliographic Collection: 
Publication Type: Journal Article
Authors: Vernot, Benjamin; Tucci, Serena; Kelso, Janet; Schraiber, Joshua G; Wolf, Aaron B; Gittelman, Rachel M; Dannemann, Michael; Grote, Steffi; McCoy, Rajiv C; Norton, Heather; Scheinfeldt, Laura B; Merriwether, David A; Koki, George; Friedlaender, Jonathan S; Wakefield, Jon; Pääbo, Svante; Akey, Joshua M
Year of Publication: 2016
Journal: Science
Volume: 352
Issue: 6282
Pagination: 235-9
Date Published: 2016 Apr 8
Publication Language: eng
ISSN: 1095-9203
Keywords: Animals, DNA, Genetic Variation, Genome, Human, Humans, Melanesia, Neanderthals, Oceanic Ancestry Group, Sequence Analysis, DNA

Although Neandertal sequences that persist in the genomes of modern humans have been identified in Eurasians, comparable studies in people whose ancestors hybridized with both Neandertals and Denisovans are lacking. We developed an approach to identify DNA inherited from multiple archaic hominin ancestors and applied it to whole-genome sequences from 1523 geographically diverse individuals, including 35 previously unknown Island Melanesian genomes. In aggregate, we recovered 1.34 gigabases and 303 megabases of the Neandertal and Denisovan genome, respectively. We use these maps of archaic sequences to show that Neandertal admixture occurred multiple times in different non-African populations, characterize genomic regions that are significantly depleted of archaic sequences, and identify signatures of adaptive introgression.

DOI: 10.1126/science.aad9416
Alternate Journal: Science
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