HLA and genetic susceptibility to sleepwalking.

Bibliographic Collection: 
MOCA Reference, APE
Publication Type: Journal Article
Authors: Lecendreux, M; Bassetti, C; Dauvilliers, Y; Mayer, G; Neidhart, E; Tafti, M
Year of Publication: 2003
Journal: Mol Psychiatry
Volume: 8
Issue: 1
Pagination: 114-7
Date Published: 2003 Jan
Publication Language: eng
ISSN: 1359-4184
Keywords: Adolescent, Adult, Aged, Child, Child, Preschool, Female, Genetic Predisposition to Disease, Histocompatibility Testing, HLA-DQ Antigens, HLA-DQ beta-Chains, Humans, Linkage Disequilibrium, Male, Middle Aged, Polymorphism, Restriction Fragment Length, Somnambulism

HLA-DQB1 typing was performed in 60 Caucasian subjects with sleepwalking (SW) disorder and their families and 60 ethnically matched subjects without any diagnosed sleep disorder. A total of 21 sleepwalkers (35.0%) were DQB1*0501 positive vs eight (13.3%) controls (P = 0.0056; odds ratio = 3.5, 95% CI = 1.4-8.7). The family data for all HLA subtypes were further assessed for allelic association with SW using the transmission-disequilibrium test. A significant excess transmission was observed for DQB1*05 and *04 alleles in familial cases, strongly suggesting that a DQB1 polymorphic amino acid might be more tightly associated than any single allele. Sequence screening revealed that Ser74 in the second exon shared by all DQB1*05 and *04 was 20 times transmitted against 4 times non-transmitted (P = 0.001) in familial cases of SW. Thus, together with narcolepsy and REM sleep behavior disorder, these findings suggest that specific DQB1 genes are implicated in disorders of motor control during sleep.

DOI: 10.1038/sj.mp.4001203
Alternate Journal: Mol. Psychiatry
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