Increase of tyrosine hydroxylase and dopamine transporter mRNA levels in ventral tegmental area of male mice under influence of repeated aggression experience.

Bibliographic Collection: 
MOCA Reference, APE
Publication Type: Journal Article
Authors: Filipenko, M L; Alekseyenko, O V; Beilina, A G; Kamynina, T P; Kudryavtseva, N N
Year of Publication: 2001
Journal: Brain Res Mol Brain Res
Volume: 96
Issue: 1-2
Pagination: 77-81
Date Published: 11/2001
Publication Language: eng
ISSN: 0169-328X
Keywords: Aggression, Animals, Dopamine Plasma Membrane Transport Proteins, Gene Expression, Male, Membrane Glycoproteins, Membrane Transport Proteins, Mice, Mice, Inbred CBA, Nerve Tissue Proteins, Reverse Transcriptase Polymerase Chain Reaction, RNA, Messenger, Stress, Psychological, Tyrosine 3-Monooxygenase, Ventral Tegmental Area

Tyrosine hydroxylase (TH) and dopamine transporter (DAT) mRNA levels in the ventral tegmental area (VTA) of midbrain were measured by multiplex RT-PCR in male mice with repeated experience of social victories (winners) and social defeats (losers) in 10 daily agonistic confrontations. Two independent experiments revealed enhanced TH and DAT mRNA levels in VTA of the winners in comparison with the losers and controls (animals after 5 days of individual housing). A positive correlation between DAT and TH mRNA levels was shown.

Alternate Journal: Brain Res. Mol. Brain Res.