Latest advances in understanding preeclampsia

Bibliographic Collection: 
MOCA Reference, APE
Publication Type: Journal Article
Authors: Redman, C. W.; Sargent, I. L.
Year of Publication: 2005
Journal: Science
Volume: 308
Issue: 5728
Pagination: 1592-4
Date Published: 06/2005
Publication Language: eng
ISSN: 1095-9203
Keywords: Animals, Female, Fetal Development, HLA Antigens, Humans, Inflammation, Killer Cells, Natural, Oxidative Stress, Placenta, Placentation, Pre-Eclampsia, Pregnancy, Proteins, Trophoblasts

Preeclampsia is a relatively common pregnancy disorder that originates in the placenta and causes variable maternal and fetal problems. In the worst cases, it may threaten the survival of both mother and baby. We summarize recent work on the causes of preeclampsia, which reveals a new mode of maternal immune recognition of the fetus, relevant to the condition. The circulating factors derived from the placenta, which contributes to the clinical syndrome, are now better understood. This brief review on preeclampsia does not cover all aspects of this intriguing condition but focuses on some new and interesting findings.

DOI: 10.1126/science.1111726
Alternate Journal: Science