Nonhuman genetics. Strong male bias drives germline mutation in chimpanzees.

Bibliographic Collection: 
Publication Type: Journal Article
Authors: Venn, Oliver; Turner, Isaac; Mathieson, Iain; de Groot, Natasja; Bontrop, Ronald; McVean, Gil
Year of Publication: 2014
Journal: Science
Volume: 344
Issue: 6189
Pagination: 1272-5
Date Published: 2014 Jun 13
Publication Language: eng
ISSN: 1095-9203
Keywords: Animals, Chromosome Mapping, Evolution, Molecular, Female, Genetic Variation, Germ-Line Mutation, Male, Models, Genetic, Models, Statistical, Pan troglodytes, Pedigree, Sex Factors

Germline mutation determines rates of molecular evolution, genetic diversity, and fitness load. In humans, the average point mutation rate is 1.2 × 10(-8) per base pair per generation, with every additional year of father's age contributing two mutations across the genome and males contributing three to four times as many mutations as females. To assess whether such patterns are shared with our closest living relatives, we sequenced the genomes of a nine-member pedigree of Western chimpanzees, Pan troglodytes verus. Our results indicate a mutation rate of 1.2 × 10(-8) per base pair per generation, but a male contribution seven to eight times that of females and a paternal age effect of three mutations per year of father's age. Thus, mutation rates and patterns differ between closely related species.

DOI: 10.1126/science.344.6189.1272
Alternate Journal: Science