Premature craniosynostosis-a complication of thyroid replacement therapy.

Bibliographic Collection: 
MOCA Reference, APE
Publication Type: Journal Article
Authors: Penfold, J L; Simpson, D A
Year of Publication: 1975
Journal: J Pediatr
Volume: 86
Issue: 3
Pagination: 360-3
Date Published: 1975 Mar
Publication Language: eng
ISSN: 0022-3476
Keywords: Child, Congenital Hypothyroidism, Craniosynostoses, Female, Head, Humans, Hypothyroidism, Infant, Infant, Newborn, Male, Skull, Thyroxine

Three hypothyroid children with premature craniosynostosis are presented, who have been treated intensively with 1-thyroxine from early infancy. It is postulated that the craniosynostosis is the result of iatrogenic hyperthyroidism during a critical period of skull growth. Various regimens of treatment for hypothyroidism are discussed with recommendations for avoiding this potentially hazardous complication of therapy.

Alternate Journal: J. Pediatr.