Systemic lupus erythematosus-like syndrome in monkeys fed alfalfa sprouts: role of a nonprotein amino acid.

Bibliographic Collection: 
MOCA Reference, APE
Publication Type: Journal Article
Authors: Malinow, M R; Bardana, E J; Pirofsky, B; Craig, S; McLaughlin, P
Year of Publication: 1982
Journal: Science
Volume: 216
Issue: 4544
Pagination: 415-7
Date Published: 1982 Apr 23
Publication Language: eng
ISSN: 0036-8075
Keywords: Animals, Canavanine, Diet, Disease Models, Animal, Lupus Erythematosus, Systemic, Macaca fascicularis, Medicago sativa

Hematologic and serologic abnormalities similar to those observed in human systemic lupus erythematosus (SLE) developed in cynomolgus macaques fed alfalfa sprouts. L-Canavanine sulfate, a constituent of alfalfa sprouts, was incorporated into the diet and reactivated the syndrome in monkeys in which an SLE-like syndrome had previously been induced by the ingestion of alfalfa seeds or sprouts.

Alternate Journal: Science
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