Systemic lupus erythematosus-like syndrome in monkeys fed alfalfa sprouts: role of a nonprotein amino acid.

Bibliographic Collection:

MOCA Reference, APE

Publication Type: Journal Article

Authors: Malinow, M R; Bardana, E J; Pirofsky, B; Craig, S; McLaughlin, P

Year of Publication: 1982

Journal: Science

Volume: 216

Issue: 4544

Pagination: 415-7

Date Published: 1982 Apr 23

Publication Language: eng

ISSN: 0036-8075

Keywords: Animals, Canavanine, Diet, Disease Models, Animal, Lupus Erythematosus, Systemic, Macaca fascicularis, Medicago sativa

Abstract:

Hematologic and serologic abnormalities similar to those observed in human systemic lupus erythematosus (SLE) developed in cynomolgus macaques fed alfalfa sprouts. L-Canavanine sulfate, a constituent of alfalfa sprouts, was incorporated into the diet and reactivated the syndrome in monkeys in which an SLE-like syndrome had previously been induced by the ingestion of alfalfa seeds or sprouts.

Custom 1:

http://www.ncbi.nlm.nih.gov/pubmed/7071589?dopt=Abstract

Alternate Journal: Science

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