Systemic Lupus Erythematosus

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Systemic lupus erythematosus is an autoimmune disorder that affects multiple organ systems of humans, and has not been described in non-human primates.  As the term implies, it is a systemic disease and the serum contains a variety of autoantibodies. It is a chronic disease with relapses, primarily affecting the skin, joints and kidneys. The prevalence may be as high as 1 in 2500 in certain populations, predominantly affecting women. Systemic Lupus erythematosus has been described as a spontaneous occurrence in the Rhesus macaque and as a disease induced by alfalfa-sprout diet in cynamolgus monkeys.

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  1. Systemic lupus erythematosus., Ruiz-Irastorza, G, Khamashta M A., Castellino G, and Hughes G R. , Lancet, 2001 Mar 31, Volume 357, Issue 9261, p.1027-32, (2001)
  2. Systemic lupus erythematosus in a rhesus macaque., Anderson, S T., and Klein E C. , Arthritis Rheum, 1993 Dec, Volume 36, Issue 12, p.1739-42, (1993)
  3. Diet-induced systemic lupus erythematosus (SLE) in primates., Bardana, E J., Malinow M R., Houghton D C., McNulty W P., Wuepper K D., Parker F, and Pirofsky B , Am J Kidney Dis, 1982 May, Volume 1, Issue 6, p.345-52, (1982)
  4. Systemic lupus erythematosus-like syndrome in monkeys fed alfalfa sprouts: role of a nonprotein amino acid., Malinow, M R., Bardana E J., Pirofsky B, Craig S, and McLaughlin P , Science, 1982 Apr 23, Volume 216, Issue 4544, p.415-7, (1982)