Diet-induced systemic lupus erythematosus (SLE) in primates.

Bibliographic Collection: 
MOCA Reference, APE
Publication Type: Journal Article
Authors: Bardana, E J; Malinow, M R; Houghton, D C; McNulty, W P; Wuepper, K D; Parker, F; Pirofsky, B
Year of Publication: 1982
Journal: Am J Kidney Dis
Volume: 1
Issue: 6
Pagination: 345-52
Date Published: 1982 May
Publication Language: eng
ISSN: 0272-6386
Keywords: Animals, Antibodies, Antinuclear, Biopsy, Coombs Test, Counterimmunoelectrophoresis, Diet, DNA, Female, Hematocrit, Kidney, Lupus Erythematosus, Systemic, Macaca fascicularis, Medicago sativa, Microscopy, Electron, Neutrophils

Ten adult, female cynomolgus macaques were randomly assigned to two equal groups: (1) semipurified diet (SPD); and (2) SPD with 45% ground alfalfa seed (AS). Both groups were studied at monthly intervals after 5 mo on their respective diets. Control animals had a mean hematocrit (Hct) of 43 +/- 2%, negative antiglobulin (AG), antinuclear antibody (ANA) and LE cell tests. Mean values for C3 and C4 were 309 +/- 47 mg/dl and 35 +/- 7 mg/dl, respectively. Mean serum binding to radiolabeled double stranded deoxyribonucleic acid (dsDNA) was 1.9 +/- 0.2%. Three of five animals fed AS developed signs of an SLE-like illness characterized by AG-positive anemia (lowest Hct 30%), positive ANA (highest titer greater than 1:15, 360; rim pattern) and elevated anti-dsDNA binding (highest 96%) with variable degrees of hypocomplementemia. One animal had granular deposition of immunoglobulin and complement at the dermal-epidermal junction of clinically normal skin the presence of immune complex-induced glomerulonephritis.

Alternate Journal: Am. J. Kidney Dis.
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