Systemic lupus erythematosus in a rhesus macaque.

Bibliographic Collection: 
MOCA Reference, APE
Publication Type: Journal Article
Authors: Anderson, S T; Klein, E C
Year of Publication: 1993
Journal: Arthritis Rheum
Volume: 36
Issue: 12
Pagination: 1739-42
Date Published: 1993 Dec
Publication Language: eng
ISSN: 0004-3591
Keywords: Animals, Disease Models, Animal, Glomerulonephritis, Membranoproliferative, Kidney, Lupus Erythematosus, Systemic, Macaca mulatta, Male

We describe the clinical course and histopathologic findings in a rhesus macaque (Macaca mulatta) which developed a systemic inflammatory disorder resembling systemic lupus erythematosus (SLE). The manifestations of the SLE included antinuclear antibody, hemolytic anemia, membranoproliferative glomerulonephritis, and arthritis. To our knowledge, spontaneously occurring SLE has not previously been described in nonhuman primates.

Alternate Journal: Arthritis Rheum.
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