Systems biology: Network evolution hinges on history.
Bibliographic Collection:
APE
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Publication Type: Journal Article
Authors: New, Aaron M; Lehner, Ben
Year of Publication: 2015
Journal: Nature
Volume: 523
Issue: 7560
Pagination: 297-8
Date Published: 2015 Jul 16
Publication Language: eng
ISSN: 1476-4687
Keywords: Evolution, Molecular, Gene Expression Regulation, Fungal, Gene Regulatory Networks, Saccharomyces cerevisiae
Abstract:
[Commentary article]
The effects of mutations in proteins can depend on the occurrence of previous mutations. It emerges that such historical contingency is also important during the evolution of gene regulatory networks.
DOI: 10.1038/nature14537
Alternate Journal: Nature
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