CLLU1 (Chronic lymphocytic leukemia up-regulated 1)
CLLU1, chronic lymphocytic leukemia up-regulated 1, is a de novo human gene originally identified as being uniquely up-regulated in patients with a particularly aggressive form of chronic lymphocytic leukemia. Increasing CLLU1 protein levels have been associated with poor clinical outcome and are currently being used as a prognostic indicator for the disease. CLLU1 evolved from ancestrally noncoding DNA, which has been verified by the presence of disabling sequences in chimp, gorilla, gibbon, macaque, and mouse. The function and evolutionary significance of CLLU1 is completely unknown.