FSHR (Follicle-stimulating hormone receptor)

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Human Uniqueness Compared to "Great Apes": 
Likely Difference
Human Universality: 
Individual Universal (All Individuals Everywhere)
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Follicle-stimulating hormone receptor (FSHR) is a transmembrane receptor necessary for activation of FSH. It is located on the ovaries, testis, and uterus and is important for proper gonadal development and function. FSHR was shown to have undergone accelerated evolution and positive selection in the human lineage and is hypothesized to be associated with decreased human gestational length compared to other primates and preterm birth.


Timing of appearance of the difference in the Hominin Lineage as a defined date or a lineage separation event. The point in time associated with lineage separation events may change in the future as the scientific community agrees upon better time estimates. Lineage separation events are defined in 2017 as:

  • the Last Common Ancestor (LCA) of humans and old world monkeys was 25,000 - 30,000 thousand (25 - 30 million) years ago
  • the Last Common Ancestor (LCA) of humans and chimpanzees was 6,000 - 8,000 thousand (6 - 8 million) years ago
  • the emergence of the genus Homo was 2,000 thousand (2 million) years ago
  • the Last Common Ancestor (LCA) of humans and neanderthals was 500 thousand years ago
  • the common ancestor of modern humans was 100 - 300 thousand years ago

Definite Appearance (Lineage Separation Event): 
Genetics Topic Attributes
Gene symbols follow the HUGO Gene Nomenclature Committee standard.
Type of Human-Specific Changes
Accelerated Evolution, Amino Acid Change


  1. An evolutionary genomic approach to identify genes involved in human birth timing., Plunkett, J., Doniger S., Orabona G., Morgan T., Haataja R., Hallman Mikko, Puttonen H., Menon R., Kuczynski E., Norwitz E., et al. , PLoS Genet, 04/2011, Volume 7, Issue 4, p.e1001365, (2011)
  2. The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology., Simoni, M, Gromoll J, and Nieschlag E , Endocr Rev, 12/1997, Volume 18, Issue 6, p.739-73, (1997)