GRIN3B (Glutamate receptor, ionotropic, N-methyl-D-aspartate 3B) | Center for Academic Research and Training in Anthropogeny (CARTA)

Certainty Style Key

Certainty styling is being phased out topic by topic.

Hover over keys for definitions:

True Likely Speculative

What is MOCA?
MOCA FAQ...

Human Uniqueness Compared to "Great Apes":

Likely Difference

MOCA Domain:

Genetics

MOCA Topic Authors:

Majesta O'Bleness

James Sikela

Glutamate receptor, ionotropic, N-methyl-D-aspartate 3A (GRIN3B) is a subunit of NMDA receptors, which are glutamate regulated ion-channels that regulate excitatory synaptic transmission. GRIN3B genetic changes have been associated with changes in social interaction and anxiety. GRIN3B has an amino acid change that lead to a gain of a phosphorylation site. Change in the human GRIN3B has been hypothesized to play a role in human higher brain function.

Timing

Timing of appearance of the difference in the Hominin Lineage as a defined date or a lineage separation event. The point in time associated with lineage separation events may change in the future as the scientific community agrees upon better time estimates. Lineage separation events are defined in 2017 as:

the Last Common Ancestor (LCA) of humans and old world monkeys was 25,000 - 30,000 thousand (25 - 30 million) years ago
the Last Common Ancestor (LCA) of humans and chimpanzees was 6,000 - 8,000 thousand (6 - 8 million) years ago
the emergence of the genus Homo was 2,000 thousand (2 million) years ago
the Last Common Ancestor (LCA) of humans and neanderthals was 500 thousand years ago
the common ancestor of modern humans was 100 - 300 thousand years ago

Definite Appearance:

6,000 thousand years ago

Genetics Topic Attributes

Gene symbols follow the HUGO Gene Nomenclature Committee standard.

Gene Symbol	Type of Human-Specific Changes
GRIN3B	Amino Acid Change

References

The identification and functional implications of human-specific "fixed" amino acid substitutions in the glutamate receptor family., Goto, H., Watanabe K., Araragi N., Kageyama R., Tanaka K., Kuroki Y., Toyoda A., Hattori M., Sakaki Y., Fujiyama A., et al. , BMC Evol Biol, Volume 9, p.224, (2009)
- PubMed
- BibTeX
- Tagged
- XML