HLA-DRB1 family
Certainty Style Key
Certainty styling is being phased out topic by topic.
Hover over keys for definitions:Human Uniqueness Compared to "Great Apes":
Speculative Difference
MOCA Domain:
The HLA-DRB1 (MHC Class II) family of genes codes for human leukocyte antigen membrane proteins of the DR family, and are involved in presentation of antigens to T cells. The results of an examination of the locus suggests a recent origin of multiple alleles. Findings implicate HLA-DRB1 lineages 8 and 11-14 as human-specific via multiple analyses, while some analyses indicate that 3, 15 and 16 are HLS and others do not. Lineages 1, 4 and 7, meanwhile, appear to be shared among multiple species. It is thought that this rapid appearance of new alleles is mediated by gene conversions and related events.
The Human Difference:
Novel Alleles
References
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An archaic HLA class I receptor allele diversifies natural killer cell-driven immunity in First Nations peoples of Oceania, , CellCell, (2024)
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Full-length sequence analysis of the HLA-DRB1 locus suggests a recent origin of alleles., , Immunogenetics, 04/2007, Volume 59, Issue 4, p.261-71, (2007)
