Kruppel-type Zinc Finger Family
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Zinc finger proteins are a family of transcription factors that regulate gene expression, and most of these proteins are members of the KZNF family. There are 7 human-specific novel KZNFs and 10 KZNFs that have undergone pseudogenization specifically in the human lineage. 30 additional KZNFs have experienced human-specific sequence changes that are presumed to be of functional significance. Members of the KZNF family are often in regions of segmental duplications, and multiple KZNFs have undergone human-specific duplications and inversions.
Copy number change