Kruppel-type Zinc Finger Family
Certainty Style Key
Certainty styling is being phased out topic by topic.
Hover over keys for definitions:Human Uniqueness Compared to "Great Apes":
Likely Difference
MOCA Domain:
Zinc finger proteins are a family of transcription factors that regulate gene expression, and most of these proteins are members of the KZNF family. There are 7 human-specific novel KZNFs and 10 KZNFs that have undergone pseudogenization specifically in the human lineage. 30 additional KZNFs have experienced human-specific sequence changes that are presumed to be of functional significance. Members of the KZNF family are often in regions of segmental duplications, and multiple KZNFs have undergone human-specific duplications and inversions.
The Human Difference:
Pseudogenization
Copy number change
Inversion
Gene deletion
Novel genes
References
-
Gain, loss and divergence in primate zinc-finger genes: a rich resource for evolution of gene regulatory differences between species., , PLoS One, Volume 6, Issue 6, p.e21553, (2011)
