MRC1 (Mannose receptor, C type 1)
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Mannose Receptor, C type 1 (MRC1) is a membrane receptor that mediates the endocytosis of glycoproteins by macrophages. MRC1 binds mannose structures on the surface of viruses, bacteria, and fungi to be neutralized by phagocytosis. Changes in MCR1 have been associated with multiple diseases including the development of leprosy, sarcoidosis, Alzheimer’s disease, and asthma. Human has more copies of MRC1 than any other primate which could have had important implications for the multiple diseases that MRC1 may be involved in.
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Detecting gene duplications in the human lineage., , Ann Hum Genet, 2010 Nov, Volume 74, Issue 6, p.555-65, (2010)
Genetic variants in mannose receptor gene (MRC1) confer susceptibility to increased risk of sarcoidosis., , BMC Med Genet, 10/2010, Volume 11, p.151, (2010)
Genetic variants in the mannose receptor gene (MRC1) are associated with asthma in two independent populations., , Immunogenetics, 12/2009, Volume 61, Issue 11-12, p.731-8, (2009)
Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD., , J Neuroinflammation, 09/2006, Volume 3, p.27, (2006)