RAB3IP (RAB3A interacting protein) | Center for Academic Research and Training in Anthropogeny (CARTA)

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MOCA Domain:

Genetics

MOCA Topic Authors:

Majesta O'Bleness

James Sikela

RAB3A Interacting Protein (RAB3IP) is a homolog of a Ras-like GTPase interactor protein which is involved in actin remodeling and mediation of polarized membrane traffic. An L1 element integrated into an intron of the RAB3A gene, resulting in a human specific transcript. The significance of this human specific transcript is not known.

Timing

Timing of appearance of the difference in the Hominin Lineage as a defined date or a lineage separation event. The point in time associated with lineage separation events may change in the future as the scientific community agrees upon better time estimates. Lineage separation events are defined in 2017 as:

the Last Common Ancestor (LCA) of humans and old world monkeys was 25,000 - 30,000 thousand (25 - 30 million) years ago
the Last Common Ancestor (LCA) of humans and chimpanzees was 6,000 - 8,000 thousand (6 - 8 million) years ago
the emergence of the genus Homo was 2,000 thousand (2 million) years ago
the Last Common Ancestor (LCA) of humans and neanderthals was 500 thousand years ago
the common ancestor of modern humans was 100 - 300 thousand years ago

Definite Appearance:

6,000 thousand years ago

Topic	Certainty
Long Interspersed Elements (LINEs) Types and Distribution	True

Gene Symbol	Type of Human-Specific Changes
RAB3IP	Expression Pattern Change

References

Identification of human-specific transcript variants induced by DNA insertions in the human genome., Kim, Dong Seon, and Hahn Yoonsoo , Bioinformatics, 2011 Jan 1, Volume 27, Issue 1, p.14-21, (2011)
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A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport., Hattula, K., Furuhjelm J., Arffman A., and Peränen J. , Mol Biol Cell, 09/2002, Volume 13, Issue 9, p.3268-80, (2002)
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