RGS6 (Regulator of G-protein signaling 6)
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Regulator of G-protein signaling 6 (RGS6) is a negative regulator of G-protein signaling in multiple pathways important to cardiac and neuronal function and cancer susceptibility. An L1 element inserted into the 5’ upstream promoter of RGS6 resulting in a change in the expression in the human lineage. The significance of this change is not understood.
Identification of human-specific transcript variants induced by DNA insertions in the human genome., , Bioinformatics, 2011 Jan 1, Volume 27, Issue 1, p.14-21, (2011)
RGS6, a modulator of parasympathetic activation in heart., , Circ Res, 11/2010, Volume 107, Issue 11, p.1345-9, (2010)
The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling., , Cell Biochem Biophys, Volume 54, Issue 1-3, p.33-46, (2009)
A functional polymorphism in RGS6 modulates the risk of bladder cancer., , Cancer Res, 09/2004, Volume 64, Issue 18, p.6820-6, (2004)