SERF1A (Small EDRK-rich factor 1A)
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Human Uniqueness Compared to "Great Apes":
Small EDRK-rich factor 1A (SERF1A) is involved in protein aggregation. SERF1A copies are found within a 500kb 15q13 inverted duplication region that is highly prone to rearrangements and deletions. Although its exact function is unknown, it has been hypothesized to have an important role in the formation of proteotoxicity diseases such as Alzheimer’s, Parkinson’s, and Huntington’s. Humans have 1-3 more copies of SERF1A than any other primate, although the significance of these copies is unknown.
Diversity of human copy number variation and multicopy genes., , Science, 10/2010, Volume 330, Issue 6004, p.641-6, (2010)
Identification of MOAG-4/SERF as a regulator of age-related proteotoxicity., , Cell, 08/2010, Volume 142, Issue 4, p.601-12, (2010)