Siglec Expression in Extra-Embryonic Fetal Tissue

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Siglecs are sialic acid-recognizing receptors typically found on immune cells.  There is one report of Siglec expression in Extra-Embryonic Fetal Tissue, i.e. Siglec-6 expression in the placental trophoblast.  This expression is not found in placentae from great apes.  Interestingly, Siglec-6 expression is further upregulated in pre-eclampsia, an apparently "human-specific" disease.


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Duration of Labor


  1. Human-specific expression of Siglec-6 in the placenta, Van der Linden, E. C. Brinkma, Hurtado-Ziola N., Hayakawa T., Wiggleton L., Benirschke K., Varki Ajit, and Varki Nissi M. , Glycobiology, Sep, Volume 17, Number 9, p.922-31, (2007)