SPANXB (SPANX family, member B)
Certainty Style Key
True Likely Speculative
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Human Uniqueness Compared to "Great Apes":
Individual Universal (All Individuals Everywhere)
Sperm protein associated with the nucleus, X-linked, family member B (SPANX-B) is a protein of unknown function that is expressed in human testis, sperm, and multiple types of cancers. SPANX-B has a human lineage specific 18-nucleotide exonic insertion and has undergone positive selection. The implications of these changes are not understood, but could have impacted human reproduction.
The SPANX gene family of cancer/testis-specific antigens: rapid evolution and amplification in African great apes and hominids., , Proc Natl Acad Sci U S A, 2004 Mar 2, Volume 101, Issue 9, p.3077-82, (2004)