THBS4 (Thrombospondin 4)
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Thrombospondin 4 (THBS4) is an extracellular-matrix glycoprotein that mediates cell adhesion, proliferation, and motility. In brain, THBS4 has been implicated in neurite growth and can elicit synaps formation. THBS4 shows significantly higher expression levels in the human adult cortex than in other primates and this change has been hypothesized to have played a role in humans have increased synaptic density and increased rates of neurite growth. THBS4 also has been shown to accumulate in amyloid plaques and has been suggested to increase human susceptibility to developing Alzheimer’s disease.
Increased cortical expression of two synaptogenic thrombospondins in human brain evolution., , Cereb Cortex, 2007 Oct, Volume 17, Issue 10, p.2312-21, (2007)