Effect of adrenocorticotrophic hormone on sodium appetite in mice.

Bibliographic Collection: 
CARTA-Inspired Publication
Publication Type: Journal Article
Authors: Denton, DA; Blair West JR; McBurnie, MI; Miller, JA; Weisinger, RS; Williams, RM
Year of Publication: 1999
Journal: Am J Physiol Regul Integr Comp Physiol
Volume: 277
Number: 4 Pt 2
Pagination: R1033-40
Date Published: Oct
Publication Language: eng
Accession Number: 10516242
Keywords: Adrenocorticotropic Hormone/blood/pharmacology/*physiology, Angiotensin-Converting Enzyme Inhibitors/pharmacology, Animals, Appetite/drug effects/*physiology, Captopril/pharmacology, Corticotropin-Releasing Hormone/pharmacology, Cosyntropin/pharmacology

A main vector of the effects of stress is secretion of corticotrophin releasing factor (CRF), adrenocorticotrophin (ACTH), and adrenal steroids. Systemic administration of ACTH (2.8 microgram/day sc) for 7 days in BALB/c mice caused a very large increase of voluntary intake of 0.3 M NaCl equivalent to turnover of total body sodium content each day. Intracerebroventricular infusion of ACTH (20 ng/day) had no effect. Intracerebroventricular infusion of ovine CRF (10 ng/h for 7 days) caused an increase of sodium intake. The large sodium appetite-stimulating effect of systemic ACTH was not influenced by concurrent systemic infusion of captopril (2 mg/day). Induction of stress by immobilization of mice on a running wheel caused an increase in Na appetite associated with a 50% decrease of thymus weight, indicative of corticosteroid effects. The present data suggest that stress and the hormone cascade initiated by stress evoke a large sodium appetite in mice, which may be an important survival mechanism in environmental conditions causing stress.


Am J Physiol. 1999 Oct;277(4 Pt 2):R1033-40.

Author Address:

Howard Florey Institute of Experimental Physiology and Medicine, Parkville, Victoria 3052, Australia 3052. d.denton@hfi.unimelb.edu.au