The genetic and evolutionary balances in human NK cell receptor diversity.

Bibliographic Collection: 
MOCA Reference, APE
Publication Type: Journal Article
Authors: Parham, Peter
Year of Publication: 2008
Journal: Semin Immunol
Volume: 20
Issue: 6
Pagination: 311-6
Date Published: 2008 Dec
Publication Language: eng
ISSN: 1044-5323
Keywords: Animals, Antigens, CD, Evolution, Molecular, Genetic Variation, Humans, Killer Cells, Natural, Receptors, Fc, Receptors, KIR, Receptors, KIR3DL1, Receptors, Natural Killer Cell, Reproduction

In primates and cattle two ancient killer-cell immunoglobulin-like receptor (KIR) lineages independently evolved to become diverse NK cell receptors. In mice, KIR genes were sidelined to the X chromosome, a possible consequence of pathogen-mediated selection on the receptor for IgA-Fc. In humans, KIR uniquely form two omnipresent haplotype groups (A and B), postulated here to play complementary and necessary roles in immune defense and reproduction. The basis of KIR3DL1/S1 polymorphism is three ancient lineages maintained by long-term balancing selection and present in all human populations. Conserved and variable NK cell receptors produce structurally diverse NK cell receptor repertoires within a defined range of missing-self-response.

DOI: 10.1016/j.smim.2008.10.002
Alternate Journal: Semin. Immunol.