Genetic Markers of Human Evolution Are Enriched in Schizophrenia

Bibliographic Collection: 
Publication Type: Journal Article
Authors: Srinivasan, Saurabh; Bettella, Francesco; Mattingsdal, Morten; Wang, Yunpeng; Witoelar, Aree; Schork, Andrew J.; Thompson, Wesley K.; Zuber, Verena; Winsvold, Bendik S.; Zwart, John-Anker; Collier, David A.; Desikan, Rahul S.; Melle, Ingrid; Werge, Thomas; Dale, Anders M.; Djurovic, Srdjan; Andreassen, Ole A.
Year of Publication: 2016
Journal: Biological PsychiatryBiological Psychiatry
Volume: 80
Issue: 4
Pagination: 284 - 292
Date Published: 08/2016
Publication Language: eng
ISBN Number: 0006-3223

Why schizophrenia has accompanied humans throughout our history despite its negative effect on fitness remains an evolutionary enigma. It is proposed that schizophrenia is a by-product of the complex evolution of the human brain and a compromise for humans? language, creative thinking, and cognitive abilities.

We analyzed recent large genome-wide association studies of schizophrenia and a range of other
human phenotypes (anthropometric measures, cardiovascular disease risk factors, immune-mediated diseases)
using a statistical framework that draws on polygenic architecture and ancillary information on genetic variants.
We used information from the evolutionary proxy measure called the Neanderthal selective sweep (NSS) score.

Gene loci associated with schizophrenia are significantly (p 5 7.30 3 1029) more prevalent in genomic
regions that are likely to have undergone recent positive selection in humans (i.e., with a low NSS score). Variants in
brain-related genes with a low NSS score confer significantly higher susceptibility than variants in other brain-related
genes. The enrichment is strongest for schizophrenia, but we cannot rule out enrichment for other phenotypes.
The false discovery rate conditional on the evolutionary proxy points to 27 candidate schizophrenia susceptibility
loci, 12 of which are associated with schizophrenia and other psychiatric disorders or linked to brain development.

Our results suggest that there is a polygenic overlap between schizophrenia and NSS score, a
marker of human evolution, which is in line with the hypothesis that the persistence of schizophrenia is related to the
evolutionary process of becoming human.


doi: 10.1016/j.biopsych.2015.10.009

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