Genome-wide scan demonstrates significant linkage for male sexual orientation.

Bibliographic Collection: 
Publication Type: Journal Article
Authors: Sanders, A R; Martin, E R; Beecham, G W; Guo, S; Dawood, K; Rieger, G; Badner, J A; Gershon, E S; Krishnappa, R S; Kolundzija, A B; Duan, J; Gejman, P V; Bailey, J M
Year of Publication: 2015
Journal: Psychol Med
Volume: 45
Issue: 7
Pagination: 1379-88
Date Published: 2015 May
Publication Language: eng
ISSN: 1469-8978
Keywords: Adult, Chromosomes, Human, Pair 8, Chromosomes, Human, X, Genetic Linkage, Genome-Wide Association Study, Homosexuality, Male, Humans, Male, Siblings, United States

BACKGROUND: Findings from family and twin studies support a genetic contribution to the development of sexual orientation in men. However, previous studies have yielded conflicting evidence for linkage to chromosome Xq28.METHOD: We conducted a genome-wide linkage scan on 409 independent pairs of homosexual brothers (908 analyzed individuals in 384 families), by far the largest study of its kind to date.RESULTS: We identified two regions of linkage: the pericentromeric region on chromosome 8 (maximum two-point LOD = 4.08, maximum multipoint LOD = 2.59), which overlaps with the second strongest region from a previous separate linkage scan of 155 brother pairs; and Xq28 (maximum two-point LOD = 2.99, maximum multipoint LOD = 2.76), which was also implicated in prior research.CONCLUSIONS: Results, especially in the context of past studies, support the existence of genes on pericentromeric chromosome 8 and chromosome Xq28 influencing development of male sexual orientation.

DOI: 10.1017/S0033291714002451
Alternate Journal: Psychol Med