Protective effect of HLA-DRB1 11 and predisposition of HLA-C 04 in the development of severe liver damage in Brazilian patients with chronic hepatitis C virus infection.

Bibliographic Collection: 
MOCA Reference, APE
Publication Type: Journal Article
Authors: Marangon, A V; Silva, G F; de Moraes, C F V; Grotto, R M T; Pardini, M I M C; de Pauli, D S; Visentainer, J E L; Sell, A M; Moliterno, R A
Year of Publication: 2012
Journal: Scand J Immunol
Volume: 76
Issue: 4
Pagination: 440-7
Date Published: 10/2012
Publication Language: eng
ISSN: 1365-3083
Keywords: Adult, Alleles, Brazil, Female, Gene Frequency, Genetic Predisposition to Disease, Haplotypes, Hepatitis C, Chronic, HLA-C Antigens, HLA-DRB1 Chains, Humans, Immunophenotyping, Liver, Liver Cirrhosis, Male, Middle Aged, Severity of Illness Index, Time Factors

The objective of this study was to investigate human leucocyte antigen (HLA) genes in patients chronically infected with hepatitis C virus (HCV) and to analyse the possible role of these genes in the progression of chronic hepatitis C. One hundred and forty-five (145) Brazilian patients infected only with HCV genotype 1 were evaluated. HLA class I (A, B, C) and class II (DRB1, DQA1, DQB1) typing were carried out by PCR-SSO, through Luminex technology. Associations were found with protection against development of liver damage by both DRB1 11 (5.0% versus 18.2%, P=0.0016, OR=0.23, CI 95% = 0.09-0.58; Pc=0.0208) and DRB1 11-DQA1 05-DQB1 03 haplotype (4.2% versus 15.3%, P=0.0032; OR = 0.24, CI 95% = 0.08-0.64). Liver damage was associated with HLA-C 04 in patients with <20 years of infection (38.4% versus 9.1%, P = 0.002, OR = 6.25, CI 95%=1.97-19.7; Pc=0.0238). It is concluded that HLA alleles can influence the development of liver damage in HCV type-1 chronically infected Brazilian patients.

DOI: 10.1111/j.1365-3083.2012.02755.x
Alternate Journal: Scand. J. Immunol.