HLA-DRB1*11 (major histocompatibility complex, class II, DR beta 1 allele 11 )
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The major histocompatibility complex, class II, DR beta 1 allele 11 (HLA-DRB1*11) has an important role in the primate immune system as it presents foreign antigens to T-cells. This particular allele is human lineage specific although polymorphic in the human population. The presence of this allele has been associated with many disease protective effects, including but not limited to, development of asthma, juvenile arthritis, multiple sclerosis and liver damage from hepatitis C infection. While the implications for this allele in the human population are unknown, they may have to do with the protective effects mentioned.
Protective effect of HLA-DRB1 11 and predisposition of HLA-C 04 in the development of severe liver damage in Brazilian patients with chronic hepatitis C virus infection., , Scand J Immunol, 10/2012, Volume 76, Issue 4, p.440-7, (2012)
Association of HLA DRB1 alleles with juvenile idiopathic arthritis in Mexicans., , Clin Exp Rheumatol, 01/2010, Volume 28, Issue 1, p.124-7, (2010)
Human leukocyte antigen type and progression from onset of symptoms to development of asthma., , Allergy Asthma Proc, 03/2010, Volume 31, Issue 2, p.120-5, (2010)
HLA-DRB1* allele-associated genetic susceptibility and protection against multiple sclerosis in Brazilian patients., , Mol Med Rep, 11/2009, Volume 2, Issue 6, p.993-8, (2009)
Full-length sequence analysis of the HLA-DRB1 locus suggests a recent origin of alleles., , Immunogenetics, 04/2007, Volume 59, Issue 4, p.261-71, (2007)