ABCB10 (ATP-binding cassette, subfamily B (MDR/TAP) member 10)

Certainty Style Key
Hover over keys for definitions:
True   Likely   Speculative
Human Uniqueness Compared to "Great Apes": 
Likely Difference
MOCA Domain: 
MOCA Topic Authors: 

ATP-binding cassette, sub-family B (MDR/TAP), member 10 is a mitochondrial inner membrane ATP-binding cassette transporter which is highly expressed during erythroid maturation in hematopoietic tissues. Abcb10 interacts with Mfrn1 to promote Mfrn1-dependent mitochondrial iron importation. Array comparative genomic hybridization indicates that Abcb10 shows higher copy number in human than in any other primate. The significance of these copies in human is unknown.

Timing

Timing of appearance of the difference in the Hominin Lineage as a defined date or a lineage separation event. The point in time associated with lineage separation events may change in the future as the scientific community agrees upon better time estimates. Lineage separation events are defined in 2017 as:

  • the Last Common Ancestor (LCA) of humans and old world monkeys was 25,000 - 30,000 thousand (25 - 30 million) years ago
  • the Last Common Ancestor (LCA) of humans and chimpanzees was 6,000 - 8,000 thousand (6 - 8 million) years ago
  • the emergence of the genus Homo was 2,000 thousand (2 million) years ago
  • the Last Common Ancestor (LCA) of humans and neanderthals was 500 thousand years ago
  • the common ancestor of modern humans was 100 - 300 thousand years ago

Definite Appearance: 
6,000 thousand years ago
Genetics Topic Attributes
Gene symbols follow the HUGO Gene Nomenclature Committee standard.
Gene Symbol Type of Human-Specific Changes
ABCB10 Copy Number Changes

References

  1. Identification of human specific gene duplications relative to other primates by array CGH and quantitative PCR., Armengol, Gemma, Knuutila Sakari, Lozano Juan-José, Madrigal Irene, and Caballín María-Rosa , Genomics, 2010 Apr, Volume 95, Issue 4, p.203-9, (2010)
  2. Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria., Chen, Wen, Paradkar Prasad N., Li Liangtao, Pierce Eric L., Langer Nathaniel B., Takahashi-Makise Naoko, Hyde Brigham B., Shirihai Orian S., Ward Diane M., Kaplan Jerry, et al. , Proc Natl Acad Sci U S A, 2009 Sep 22, Volume 106, Issue 38, p.16263-8, (2009)
  3. Lineage-specific gene duplication and loss in human and great ape evolution., Fortna, A., Kim Y., MacLaren E., Marshall K., Hahn G., Meltesen L., Brenton M., Hink R., Burgers S., Hernandez-Boussard T., et al. , PLoS Biol, 07/2004, Volume 2, Issue 7, p.E207, (2004)