ARHGEF5 (Rho guanine nucleotide exchange factor (GEF) 5)
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Rho guanine nucleotide exchange factor 5 (Arhgef5) is crucial for podosome formation, which are membrane protrusions that play a crucial role in cell adhesion and migration and extracellular matrix remodeling. There are 2-6 more copies in the human genome of Arhgef5 than in any other primate. The significance of these copies in human is unknown.
The guanine nucleotide exchange factor Arhgef5 plays crucial roles in Src-induced podosome formation., , J Cell Sci, 2011 May 15, Volume 124, Issue Pt 10, p.1726-38, (2011)
Diversity of human copy number variation and multicopy genes., , Science, 10/2010, Volume 330, Issue 6004, p.641-6, (2010)
Lineage-specific gene duplication and loss in human and great ape evolution., , PLoS Biol, 07/2004, Volume 2, Issue 7, p.E207, (2004)