DDX11L (DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 like)

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What is MOCA?
MOCA FAQ...
Human Uniqueness Compared to "Great Apes": 
Likely Difference
MOCA Domain: 
Genetics
MOCA Topic Authors: 
Majesta O'Bleness
James Sikela

DEAD/H box polypeptide 11-like gene (DDX11L) is a gene that propagated in the subtelomeric regions of the human genome. It is present and expressed from the subtelomeric regions of at least 14 chromosomes. Its precursor gene, DDX11, is a RNA helicase and is hypothesized to function in maintenance of chromosome transmission fidelity and genome stability. The ramifications of the copy number expansion of this gene in the human lineage is as of yet unknown.

Timing

Timing of appearance of the difference in the Hominin Lineage as a defined date or a lineage separation event. The point in time associated with lineage separation events may change in the future as the scientific community agrees upon better time estimates. Lineage separation events are defined in 2017 as:

  • the Last Common Ancestor (LCA) of humans and old world monkeys was 25,000 - 30,000 thousand (25 - 30 million) years ago
  • the Last Common Ancestor (LCA) of humans and chimpanzees was 6,000 - 8,000 thousand (6 - 8 million) years ago
  • the emergence of the genus Homo was 2,000 thousand (2 million) years ago
  • the Last Common Ancestor (LCA) of humans and neanderthals was 500 thousand years ago
  • the common ancestor of modern humans was 100 - 300 thousand years ago

Definite Appearance: 
6,000 thousand years ago
Related MOCA Topics
Referenced By:
Topic Certainty
Telomere and Subtelomere Changes True
Genetics Topic Attributes
Gene symbols follow the HUGO Gene Nomenclature Committee standard.
Gene Symbol Type of Human-Specific Changes
DDX11 Copy Number Changes

References

  1. Identification of human specific gene duplications relative to other primates by array CGH and quantitative PCR., Armengol, Gemma, Knuutila Sakari, Lozano Juan-José, Madrigal Irene, and Caballín María-Rosa , Genomics, 2010 Apr, Volume 95, Issue 4, p.203-9, (2010)
  2. DDX11L: a novel transcript family emerging from human subtelomeric regions., Costa, Valerio, Casamassimi Amelia, Roberto Roberta, Gianfrancesco Fernando, Matarazzo Maria R., d'Urso Michele, D'Esposito Maurizio, Rocchi Mariano, and Ciccodicola Alfredo , BMC Genomics, 2009, Volume 10, p.250, (2009)
  3. Lineage-specific gene duplication and loss in human and great ape evolution., Fortna, A., Kim Y., MacLaren E., Marshall K., Hahn G., Meltesen L., Brenton M., Hink R., Burgers S., Hernandez-Boussard T., et al. , PLoS Biol, 07/2004, Volume 2, Issue 7, p.E207, (2004)

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