E2F6 (E2F transcription factor 6)
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E2F transcription factor 6 (E2F6) is an atypical member of the E2F family of transcription factors in that it lacks the typical tumor suppressor protein domain that is present in this family and instead has a modular suppression domain. E2F6 acts as a transcriptional repressor of other members of the E2F family and plays a critical role in the regulation of apoptosis. Array comparative genomic hybridization studies have shown E2F6 at higher copy number in the human genome than in any other primate, however, the significance of this increased copy number is not understood.
Identification of human specific gene duplications relative to other primates by array CGH and quantitative PCR., , Genomics, 2010 Apr, Volume 95, Issue 4, p.203-9, (2010)
Activating E2Fs mediate transcriptional regulation of human E2F6 repressor., , Am J Physiol Cell Physiol, 2006 Jan, Volume 290, Issue 1, p.C189-99, (2006)
Lineage-specific gene duplication and loss in human and great ape evolution., , PLoS Biol, 07/2004, Volume 2, Issue 7, p.E207, (2004)